Bluenorder: ←Created page with ''''Zhenyu Yue''', PhD, is a distinguished academic researcher in the field of neurology and neuroscience, currently serving as the Alex and Shirley Aidekman Professor at the Icahn School of Medicine at Mount Sinai, New York.<ref>{{Cite web |title=Zhenyu Yue {{!}} Mount Sinai - New York |url=https://profiles.mountsinai.org/zhenyu-yue |access-date=2024-04-28 |website=Mount Sinai Health System |language=en}}</ref> He is known for his discovery of g...'
'''Zhenyu Yue''', PhD, is a [[distinguished]] academic researcher in the field of neurology and neuroscience, currently serving as the Alex and Shirley Aidekman Professor at the [[Icahn School of Medicine]] at [[Mount Sinai, New York]].<ref>{{Cite web |title=Zhenyu Yue {{!}} Mount Sinai - New York |url=https://profiles.mountsinai.org/zhenyu-yue |access-date=2024-04-28 |website=Mount Sinai Health System |language=en}}</ref> He is known for his discovery of genes controlling [[autophagy]] (cell self-eating), autophagy functions in [[central nervous system]], molecular mechanism of neurodegenerative diseases, and modelling neurological diseases using genetic mouse models.<ref>{{Cite journal |last=Zhou |first=Xiaoting |last2=Lee |first2=You-Kyung |last3=Li |first3=Xianting |last4=Kim |first4=Henry |last5=Sanchez-Priego |first5=Carlos |last6=Han |first6=Xian |last7=Tan |first7=Haiyan |last8=Zhou |first8=Suiping |last9=Fu |first9=Yingxue |last10=Purtell |first10=Kerry |last11=Wang |first11=Qian |last12=Holstein |first12=Gay R. |last13=Tang |first13=Beisha |last14=Peng |first14=Junmin |last15=Yang |first15=Nan |date=2024-04-10 |title=Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons |url=https://www.nature.com/articles/s41467-024-47440-z |journal=Nature Communications |language=en |volume=15 |issue=1 |pages=3113 |doi=10.1038/s41467-024-47440-z |issn=2041-1723}}</ref><ref>{{Cite web |date=2019-06-10 |title=Yue Laboratory |url=https://labs.icahn.mssm.edu/yuelab/ |access-date=2024-04-28 |website=labs.icahn.mssm.edu |language=en-US}}</ref>
== Early life & education ==
Zhenyu Yue earned a [[Bachelor of Science|Bachelor of Science (B.S.)]] degree in Cell Biology from [[Wuhan University]] in China in 1988. He then obtained a Master of Science (M.S.) degree in Vertebrate Genetics from the Institute of Hydrobiology at the [[Chinese Academy of Science]], also in [[Wuhan, China]], in 1991.<ref>{{Cite web |title=research.com |url=https://research.com/u/zhenyu-yue}}</ref> In pursuit of further education, Yue relocated to the United States, where he embarked on doctoral studies in [[Molecular Biology]] and [[Biochemistry]]. He conducted his Ph.D. research under the mentorship of Aaron J Shatkin, a member of the National Academy of Sciences, at UMDNJ-Rutgers, [[Robert Wood Johnson Medical School]] in New Jersey.<ref>{{Cite web |title=Zhenyu Yue, PhD {{!}} Parkinson's Disease |url=https://www.michaeljfox.org/researcher/zhenyu-yue-phd |access-date=2024-04-28 |website=www.michaeljfox.org |language=en}}</ref> His doctoral studies, which spanned from 1992 to 1997, focused on virus biology and [[Messenger RNA|mRNA]] modifications. The highlight of this Ph.D. thesis is the identification of human mRNA capping enzyme, which is a significant contribution to the understanding of mRNA biology, and has yielded the patent “mRNA Capping and Use thereof”.<ref>{{Cite patent|number=US6312926B1|title=mRNA capping enzymes and uses thereof|gdate=2001-11-06|invent1=Shatkin|invent2=Pillutla|invent3=Reinberg|invent4=Maldonado|inventor1-first=Aaron J.|inventor2-first=Renuka|inventor3-first=Danny|inventor4-first=Edio|url=https://patents.google.com/patent/US6312926B1/en}}</ref>
Following the completion of his Ph.D., Yue engaged in postdoctoral research at the [[Howard Hughes Medical Institute]]/[[The Rockefeller University]] in New York. From 1998 to 2002, he worked under the guidance of Nathaniel Heintz, Ph.D., a Howard Hughes Medical Institute investigator, specializing in molecular biology and neuroscience. He reported the first autophagy gene disruption mouse models, which revealed a link of autophagy to [[Carcinogenesis|tumorigenesis]].<ref>{{Cite journal |last=Deng |first=Zhiqiang |last2=Dong |first2=Yu |last3=Zhou |first3=Xiaoting |last4=Lu |first4=Jia-Hong |last5=Yue |first5=Zhenyu |date=2022-04-01 |title=Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles |url=https://www.sciencedirect.com/science/article/pii/S2211383521004810 |journal=Acta Pharmaceutica Sinica B |volume=12 |issue=4 |pages=1688–1706 |doi=10.1016/j.apsb.2021.12.009 |issn=2211-3835 |pmc=PMC9279633 |pmid=35847516}}</ref> Yue pioneered autophagy research in neurodegeneration using ''Lurcher'' mice.<ref>{{Cite journal |last=Yue |first=Zhenyu |last2=Horton |first2=Antony |last3=Bravin |first3=Monica |last4=DeJager |first4=Philip L. |last5=Selimi |first5=Fekrije |last6=Heintz |first6=Nathaniel |date=2002-08 |title=A Novel Protein Complex Linking the δ2 Glutamate Receptor and Autophagy |url=https://doi.org/10.1016/s0896-6273(02)00861-9 |journal=Neuron |volume=35 |issue=5 |pages=921–933 |doi=10.1016/s0896-6273(02)00861-9 |issn=0896-6273}}</ref>
== Research & Career ==
Zhenyu Yue's research has primarily concentrated on the molecular and cellular mechanisms underlying neurodegenerative diseases, with a particular focus on [[Parkinson’s disease]] and [[Alzheimer's disease|Alzheimer’s disease]].<ref>{{Cite web |title=Center for Parkinson’s Disease Neurobiology {{!}} Icahn School of Medicine |url=https://icahn.mssm.edu/research/center-parkinsons-disease |access-date=2024-04-28 |website=Icahn School of Medicine at Mount Sinai |language=en-US}}</ref>
One of the notable areas of Yue's research involves the study of autophagy, a cellular process that degrades and recycles cellular components. His work has led to the identification of novel autophagy regulators, such as the components in Beclin 1-hVPS34 complex (class 3 PI3K), Atg14L, Rubicon, and [[NRBF2]], which play crucial roles in the autophagy pathway.<ref>{{Cite journal |last=Funderburk |first=Sarah F. |last2=Wang |first2=Qing Jun |last3=Yue |first3=Zhenyu |date=2010-06 |title=The Beclin 1–VPS34 complex – at the crossroads of autophagy and beyond |url=https://doi.org/10.1016/j.tcb.2010.03.002 |journal=Trends in Cell Biology |volume=20 |issue=6 |pages=355–362 |doi=10.1016/j.tcb.2010.03.002 |issn=0962-8924 |pmc=PMC3781210 |pmid=20356743}}</ref><ref>{{Cite journal |last=Zhong |first=Yun |last2=Wang |first2=Qing Jun |last3=Li |first3=Xianting |last4=Yan |first4=Ying |last5=Backer |first5=Jonathan M. |last6=Chait |first6=Brian T. |last7=Heintz |first7=Nathaniel |last8=Yue |first8=Zhenyu |date=2009-04 |title=Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex |url=https://www.nature.com/articles/ncb1854 |journal=Nature Cell Biology |language=en |volume=11 |issue=4 |pages=468–476 |doi=10.1038/ncb1854 |issn=1476-4679 |pmc=PMC2664389 |pmid=19270693}}</ref> This research is significant for understanding how disruptions in cellular cleaning mechanisms can contribute to the development of neurodegenerative diseases.
Yue's research has contributed to identifying and characterizing autophagy receptors, which are implicated in neurodegenerative diseases and psychiatric disorders. For instance, SQSTM1/p62, often found in Lewy bodies, tau tangles, and huntingtin aggregates, is the prototype of autophagy receptor that regulates the clearance of polyubiquitinated protein complex and aggregate through autophagy.<ref>{{Cite journal |last=Deng |first=Zhiqiang |last2=Lim |first2=Junghyun |last3=Wang |first3=Qian |last4=Purtell |first4=Kerry |last5=Wu |first5=Shuai |last6=Palomo |first6=Gloria M. |last7=Tan |first7=Haiyan |last8=Manfredi |first8=Giovanni |last9=Zhao |first9=Yanxiang |last10=Peng |first10=Junmin |last11=Hu |first11=Bo |last12=Chen |first12=Shi |last13=Yue |first13=Zhenyu |date=2020-05-03 |title=ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway |url=https://www.tandfonline.com/doi/full/10.1080/15548627.2019.1644076 |journal=Autophagy |language=en |volume=16 |issue=5 |pages=917–931 |doi=10.1080/15548627.2019.1644076 |issn=1554-8627 |pmc=PMC7144840 |pmid=31362587}}</ref> AKAP11, a significant risk gene for bipolar and [[schizophrenia]], is an autophagy receptor that control PKA-RI complex degradation through autophagy.<ref>{{Cite journal |last=Zhou |first=Xiaoting |last2=Lee |first2=You-Kyung |last3=Li |first3=Xianting |last4=Kim |first4=Henry |last5=Sanchez-Priego |first5=Carlos |last6=Han |first6=Xian |last7=Tan |first7=Haiyan |last8=Zhou |first8=Suiping |last9=Fu |first9=Yingxue |last10=Purtell |first10=Kerry |last11=Wang |first11=Qian |last12=Holstein |first12=Gay R. |last13=Tang |first13=Beisha |last14=Peng |first14=Junmin |last15=Yang |first15=Nan |date=2024-04-10 |title=Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons |url=https://www.nature.com/articles/s41467-024-47440-z |journal=Nature Communications |language=en |volume=15 |issue=1 |pages=3113 |doi=10.1038/s41467-024-47440-z |issn=2041-1723}}</ref>
In addition to these areas, Yue's research has extended to identifying and characterizing therapeutic targets for Parkinson’s disease (PD). For instance, he has explored the role of [[LRRK2]] and [[synaptojanin 1]] signalling pathway in neurodegeneration.<ref>{{Cite journal |last=Pan |first=Ping-Yue |last2=Li |first2=Xianting |last3=Wang |first3=Jing |last4=Powell |first4=James |last5=Wang |first5=Qian |last6=Zhang |first6=Yuanxi |last7=Chen |first7=Zhaoyu |last8=Wicinski |first8=Bridget |last9=Hof |first9=Patrick |last10=Ryan |first10=Timothy A. |last11=Yue |first11=Zhenyu |date=2017-11-22 |title=Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons |url=https://www.jneurosci.org/content/37/47/11366 |journal=Journal of Neuroscience |language=en |volume=37 |issue=47 |pages=11366–11376 |doi=10.1523/JNEUROSCI.0964-17.2017 |issn=0270-6474 |pmc=PMC5700420 |pmid=29054882}}</ref> Yue’s investigation demonstrated that [[vitamin B12]] modulates LRRK2 kinase activity through [[allosteric regulation]] and confers neuroprotection.<ref>{{Cite journal |last=Schaffner |first=Adam |last2=Li |first2=Xianting |last3=Gomez-Llorente |first3=Yacob |last4=Leandrou |first4=Emmanouela |last5=Memou |first5=Anna |last6=Clemente |first6=Nicolina |last7=Yao |first7=Chen |last8=Afsari |first8=Farinaz |last9=Zhi |first9=Lianteng |last10=Pan |first10=Nina |last11=Morohashi |first11=Keita |last12=Hua |first12=Xiaoluan |last13=Zhou |first13=Ming-Ming |last14=Wang |first14=Chunyu |last15=Zhang |first15=Hui |date=2019-04 |title=Vitamin B12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection |url=https://www.nature.com/articles/s41422-019-0153-8 |journal=Cell Research |language=en |volume=29 |issue=4 |pages=313–329 |doi=10.1038/s41422-019-0153-8 |issn=1748-7838 |pmc=PMC6462009 |pmid=30858560}}</ref> Furthermore, Yue’s group has performed molecular profiling of substant nigra from the PD post-mortem brains using single nucleus RNA sequencing, and identified diverse [[dopamine]] neuron subpopulations and a novel vulnerable neuron type.<ref>{{Cite journal |last=Wang |first=Qian |last2=Wang |first2=Minghui |last3=Choi |first3=Insup |last4=Sarrafha |first4=Lily |last5=Liang |first5=Marianna |last6=Ho |first6=Lap |last7=Farrell |first7=Kurt |last8=Beaumont |first8=Kristin G. |last9=Sebra |first9=Robert |last10=De Sanctis |first10=Claudia |last11=Crary |first11=John F. |last12=Ahfeldt |first12=Tim |last13=Blanchard |first13=Joel |last14=Neavin |first14=Drew |last15=Powell |first15=Joseph |date=2024-01-12 |title=Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson’s disease |url=https://www.science.org/doi/10.1126/sciadv.adi8287 |journal=Science Advances |language=en |volume=10 |issue=2 |doi=10.1126/sciadv.adi8287 |issn=2375-2548 |pmc=PMC10780895 |pmid=38198537}}</ref> His studies provided valuable resource and insight into therapeutic targets of PD.
After concluding his postdoctoral tenure at [[The Rockefeller University]] in New York, Yue joined the Mount Sinai School of Medicine in New York, where he has developed a significant portion of his professional work.
Yue's initial appointment at Mount Sinai began in August 2004 as an Assistant Professor in the Department of Neurology & Neuroscience. His career at Mount Sinai evolved with his promotion to Associate Professor with tenure in August 2008, a position he maintained until ascending to the role of full Professor of Neurology and Neuroscience in July 2013.
In his capacity at Mount Sinai, Yue has undertaken several leadership roles, notably as the Director of Basic and Translational Research in Movement Disorders since December 2012 and, more recently, as the Director of the Center for Parkinson’s Disease Neurobiology since July 2022.
== Awards ==
Throughout his career, Zhenyu Yue has received several awards and honors that acknowledge his contributions to the fields of neurology and neuroscience, particularly in the context of his research on neurodegenerative diseases.
* In 2008, Yue was honored with the Faculty Council Award for Academic Excellence by Mount Sinai.
* Yue holds the Alex and Shirley Aidekman Family Neurological Research Professorship at Mount Sinai.
* Yue has been a recipient of the Sundaram Research Scholar Award from the Mount Sinai Medical Center in 2017, 2018, and 2019.
* Yue has been a member of Sigma Xi, The Scientific Research Honor Society, since March 2024.
In addition to his institutional honors, Yue has been actively involved with the [[Chinese Biological Investigators Society|Chinese Biological Investigator Society]] (CBIS), serving as a board member since 2016.
== Notable publications ==
* '''Zhenyu Yue''', Maldonado. E., Pillutla, RC., Cho, H., Reinberg, D. and Shatkin, AJ (1997) Mammalian capping enzyme complements mutant ''S. cerevisiae'' lacking mRNA Guanylytransferase and selectively binds the elongating form of RNA polymerase II. '''''Proc. Natl. Acad. Sci. USA''''' 94:12914-9.<ref>{{Cite journal |last=Yue |first=Z. |last2=Maldonado |first2=E. |last3=Pillutla |first3=R. |last4=Cho |first4=H. |last5=Reinberg |first5=D. |last6=Shatkin |first6=A. J. |date=1997-11-25 |title=Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II |url=https://pubmed.ncbi.nlm.nih.gov/9371772 |journal=Proceedings of the National Academy of Sciences of the United States of America |volume=94 |issue=24 |pages=12898–12903 |doi=10.1073/pnas.94.24.12898 |issn=0027-8424 |pmc=PMC24235 |pmid=9371772}}</ref>
* '''Zhenyu Yue''', Antony Horton, Monica Bravin, Philip L. DeJager, Fekrije Selimi, and Nathaniel Heintz (2002) A Novel Protein Complex linking the d2 Glutamate Receptor (GluRd2) and Autophagy: Implications for Neurodegeneration in Lurcher Mice. '''''Neuron''''' 35 (5):921-33''.''<ref>{{Cite journal |last=Yue |first=Zhenyu |last2=Horton |first2=Antony |last3=Bravin |first3=Monica |last4=DeJager |first4=Philip L. |last5=Selimi |first5=Fekrije |last6=Heintz |first6=Nathaniel |date=2002-08-29 |title=A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice |url=https://pubmed.ncbi.nlm.nih.gov/12372286 |journal=Neuron |volume=35 |issue=5 |pages=921–933 |doi=10.1016/s0896-6273(02)00861-9 |issn=0896-6273 |pmid=12372286}}</ref>
* '''Zhenyu Yue''', Victor Jin, Chingwen Yang, Arnold Levine and Nathaniel Heintz (2003) Beclin1, an autophagy gene essential for early embryonic development, is a haplo-insufficient tumor suppressor. '''''Proc. Natl. Acad. Sci. USA''''' 100 (25):15077-15082''.''<ref>{{Cite journal |last=Yue |first=Zhenyu |last2=Jin |first2=Shengkan |last3=Yang |first3=Chingwen |last4=Levine |first4=Arnold J. |last5=Heintz |first5=Nathaniel |date=2003-12-09 |title=Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor |url=https://pubmed.ncbi.nlm.nih.gov/14657337 |journal=Proceedings of the National Academy of Sciences of the United States of America |volume=100 |issue=25 |pages=15077–15082 |doi=10.1073/pnas.2436255100 |issn=0027-8424 |pmc=PMC299911 |pmid=14657337}}</ref>
* Masaaki Komatsu, Satoshi Waguri, Masato Koike, Yu-shin Sou, Takashi Ueno, Taichi Hara, Noboru Mizushima, Jun-ichi Iwata, Junji Ezaki, Shigeo Murata, Jun Hamazaki, Yasumasa Nishito, Shun-ichiro Iemura, Tohru Natsume, Toru Yanagawa, Junya Uwayama, Eiji Warabi, Hiroshi Yoshida, Tetsuro Ishii, '''Zhenyu Yue''', Yasuo Uchiyama, Eiki Kominami and Keiji Tanaka (2007) Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice Cell 131 (6): 1149-63.<ref>{{Cite journal |last=Komatsu |first=Masaaki |last2=Waguri |first2=Satoshi |last3=Koike |first3=Masato |last4=Sou |first4=Yu-Shin |last5=Ueno |first5=Takashi |last6=Hara |first6=Taichi |last7=Mizushima |first7=Noboru |last8=Iwata |first8=Jun-Ichi |last9=Ezaki |first9=Junji |last10=Murata |first10=Shigeo |last11=Hamazaki |first11=Jun |last12=Nishito |first12=Yasumasa |last13=Iemura |first13=Shun-Ichiro |last14=Natsume |first14=Tohru |last15=Yanagawa |first15=Toru |date=2007-12-14 |title=Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice |url=https://pubmed.ncbi.nlm.nih.gov/18083104 |journal=Cell |volume=131 |issue=6 |pages=1149–1163 |doi=10.1016/j.cell.2007.10.035 |issn=0092-8674 |pmid=18083104}}</ref>
* Yun Zhong, Qing-Jun Wang, Xianting Li, Brian T. Chait, Nathaniel Heintz and '''Zhenyu Yue''' (2009) Distinct Regulation of Autophagic Activity by Novel Components Atg14L and Rubicon in Beclin 1-Vps34/phosphatidylinositol (PtdIns) 3-kinase complex. '''''Nature Cell Biology''''' 11(4):468-76.<ref>{{Cite journal |last=Zhong |first=Yun |last2=Wang |first2=Qing Jun |last3=Li |first3=Xianting |last4=Yan |first4=Ying |last5=Backer |first5=Jonathan M. |last6=Chait |first6=Brian T. |last7=Heintz |first7=Nathaniel |last8=Yue |first8=Zhenyu |date=2009-04 |title=Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex |url=https://pubmed.ncbi.nlm.nih.gov/19270693 |journal=Nature Cell Biology |volume=11 |issue=4 |pages=468–476 |doi=10.1038/ncb1854 |issn=1476-4679 |pmc=2664389 |pmid=19270693}}</ref>
* Xianting Li, Jyoti C. Patel, Jing Wang, Marat V. Avshalumov, Charles Nicholson, Joeseph D. Buxbaum, Gregory A. Elder, Margaret E. Rice and '''Zhenyu Yue''' (2010) Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice is Eliminated by familial Parkinson’s Disease Mutation G2019S. '''''Journal of Neuroscience''''' 30(5):1788-1797.<ref>{{Cite journal |last=Li |first=Xianting |last2=Patel |first2=Jyoti C. |last3=Wang |first3=Jing |last4=Avshalumov |first4=Marat V. |last5=Nicholson |first5=Charles |last6=Buxbaum |first6=Joseph D. |last7=Elder |first7=Gregory A. |last8=Rice |first8=Margaret E. |last9=Yue |first9=Zhenyu |date=2010-02-03 |title=Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858426/ |journal=The Journal of Neuroscience |volume=30 |issue=5 |pages=1788–1797 |doi=10.1523/JNEUROSCI.5604-09.2010 |issn=0270-6474 |pmc=2858426 |pmid=20130188}}</ref>
* Jiahong Lu, Liqiang He, Qing Jun Wang, Christian Behrends, Brian T. Chait, Masatake Araki, Kimi Araki, Scott L. Friedman, Maria Isabel Fiel, Min Li and '''Zhenyu Yue''' (2014) NRBF2 Regulates Autophagy and Prevents Liver Injury by Modulating Beclin 1/Atg14L-Linked Class III Phosphatidylinositol-3 Kinase Activity. '''''Nature Communications''''' 22;5:3920.<ref>{{Cite journal |last=Lu |first=Jiahong |last2=He |first2=Liqiang |last3=Behrends |first3=Christian |last4=Araki |first4=Masatake |last5=Araki |first5=Kimi |last6=Jun Wang |first6=Qing |last7=Catanzaro |first7=Joseph M. |last8=Friedman |first8=Scott L. |last9=Zong |first9=Wei-Xing |last10=Fiel |first10=M. Isabel |last11=Li |first11=Min |last12=Yue |first12=Zhenyu |date=2014-05-22 |title=NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity |url=https://pubmed.ncbi.nlm.nih.gov/24849286 |journal=Nature Communications |volume=5 |pages=3920 |doi=10.1038/ncomms4920 |issn=2041-1723 |pmc=4376476 |pmid=24849286}}</ref>
* Junghyun Lim, M. Lenard Lachenmayer, Wenchao Liu, Mondira Kundu, Rong Wang, Massaki Komatsu, Young J. Oh, Yanxiang Zhao and '''Zhenyu Yue''' (2015) Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates '''''PLoS Genetics''''' Feb 27;11(2):e1004987.<ref>{{Cite journal |last=Grapin |first=C. |date=1989 |title=[Treatment of anomalies associated with ectopies] |url=https://pubmed.ncbi.nlm.nih.gov/2572348 |journal=Chirurgie Pediatrique |volume=30 |issue=3 |pages=164 |issn=0180-5738 |pmid=2572348}}</ref>
* Mitchell S. Wold, Junghyun Lim, Véronik Lachance, Zhiqiang Deng, '''Zhenyu Yue''' (2016) ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington’s disease models '''''Molecular Neurodegeneration''''' v.11; 2016.<ref>{{Cite journal |last=Wold |first=Mitchell S. |last2=Lim |first2=Junghyun |last3=Lachance |first3=Véronik |last4=Deng |first4=Zhiqiang |last5=Yue |first5=Zhenyu |date=2016-12-09 |title=ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington’s disease models |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148922/ |journal=Molecular Neurodegeneration |volume=11 |pages=76 |doi=10.1186/s13024-016-0141-0 |issn=1750-1326 |pmc=5148922 |pmid=27938392}}</ref>
* Ping-Yue Pan, Xianting Li, Jing Wang, James Powell, Qian Wang, Yuanxi Zhang, Zhaoyu Chen, Bridget Wicinski, Patrick Hof, Timothy A. Ryan, '''Zhenyu Yue''' (2017) Parkinson’s disease associated LRRK2 hyperactive kinase mutant disrupts synaptic vesicle trafficking in ventral midbrain neurons. '''''J of Neuroscience'''.'' 2017 Nov 22;37(47):11366-11376.<ref>{{Cite journal |last=Pan |first=Ping-Yue |last2=Li |first2=Xianting |last3=Wang |first3=Jing |last4=Powell |first4=James |last5=Wang |first5=Qian |last6=Zhang |first6=Yuanxi |last7=Chen |first7=Zhaoyu |last8=Wicinski |first8=Bridget |last9=Hof |first9=Patrick |last10=Ryan |first10=Timothy A. |last11=Yue |first11=Zhenyu |date=2017-11-22 |title=Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons |url=https://pubmed.ncbi.nlm.nih.gov/29054882 |journal=The Journal of Neuroscience: The Official Journal of the Society for Neuroscience |volume=37 |issue=47 |pages=11366–11376 |doi=10.1523/JNEUROSCI.0964-17.2017 |issn=1529-2401 |pmc=5700420 |pmid=29054882}}</ref>
* Adam Schaffner, Xianting Li, Yacob Gomez-Llorent, Emmanouela Leandrou, Anna Memou<sup>,</sup> Nicolina Clemente, Chen Yao, Farinaz Afsari, Lianteng Zhi, Nina Pan, Keita Morohashi, Xiaoluan Hua, Ming-Ming Zhou, Chunyu Wang, Hui Zhang, Shu G. Chen, Christopher J. Elliott, Hardy Rideout, Iban Ubarretxena-Belandia, and '''Zhenyu Yue''' (2019) Vitamin B<sub>12</sub> modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection '''''Cell Research''''' 29(4):313.<ref>{{Cite journal |last=Schaffner |first=Adam |last2=Li |first2=Xianting |last3=Gomez-Llorente |first3=Yacob |last4=Leandrou |first4=Emmanouela |last5=Memou |first5=Anna |last6=Clemente |first6=Nicolina |last7=Yao |first7=Chen |last8=Afsari |first8=Farinaz |last9=Zhi |first9=Lianteng |last10=Pan |first10=Nina |last11=Morohashi |first11=Keita |last12=Hua |first12=Xiaoluan |last13=Zhou |first13=Ming-Ming |last14=Wang |first14=Chunyu |last15=Zhang |first15=Hui |date=2019-04 |title=Vitamin B12 modulates Parkinson's disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection |url=https://pubmed.ncbi.nlm.nih.gov/30858560 |journal=Cell Research |volume=29 |issue=4 |pages=313–329 |doi=10.1038/s41422-019-0153-8 |issn=1748-7838 |pmc=6462009 |pmid=30858560}}</ref>
* Zhiqiang Deng, Junghyun Lim<sub>,</sub> Qian Wang, Kerry Purtell, Shuai Wu, Mitchell S. Wold, Gloria M. Palomo Carrasco, Haiyan Tan, Giovanni Manfredi, Yanxiang Zhao, Junmin Peng, Bo Hu, Shi Chen and '''Zhenyu Yue''' (2019) <sup> </sup> ALS/FTLD-linked mutations of p62/SQSTM1 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway '''''Autophagy''''' 2019 July 30:1-5.<ref>{{Cite journal |last=Deng |first=Zhiqiang |last2=Lim |first2=Junghyun |last3=Wang |first3=Qian |last4=Purtell |first4=Kerry |last5=Wu |first5=Shuai |last6=Palomo |first6=Gloria M. |last7=Tan |first7=Haiyan |last8=Manfredi |first8=Giovanni |last9=Zhao |first9=Yanxiang |last10=Peng |first10=Junmin |last11=Hu |first11=Bo |last12=Chen |first12=Shi |last13=Yue |first13=Zhenyu |date=2020-05 |title=ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway |url=https://pubmed.ncbi.nlm.nih.gov/31362587 |journal=Autophagy |volume=16 |issue=5 |pages=917–931 |doi=10.1080/15548627.2019.1644076 |issn=1554-8635 |pmc=7144840 |pmid=31362587}}</ref>
* Zhiqiang Deng, Xianting Li, Marian Blanca Ramirez, Kerry Purtell, Insup Choi, Qin Yu, and '''Zhenyu Yue''' (2021) Selective Autophagy of AKAP11 Activates cAMP/PKA to Fuel Mitochondrial Metabolism and Tumor Cell Growth '''''Proc Natl Acad Sci USA''''' Apr 6;118(14):e2020215118.<ref>{{Cite journal |last=Deng |first=Zhiqiang |last2=Li |first2=Xianting |last3=Blanca Ramirez |first3=Marian |last4=Purtell |first4=Kerry |last5=Choi |first5=Insup |last6=Lu |first6=Jia-Hong |last7=Yu |first7=Qin |last8=Yue |first8=Zhenyu |date=2021-04-06 |title=Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth |url=https://pubmed.ncbi.nlm.nih.gov/33785595 |journal=Proceedings of the National Academy of Sciences of the United States of America |volume=118 |issue=14 |pages=e2020215118 |doi=10.1073/pnas.2020215118 |issn=1091-6490 |pmc=8040602 |pmid=33785595}}</ref>
* Insup Choi, Minghui Wang, Seungyeul Yoo, Peng Xu, Steven P. Seegobin, Xianting Li, Xian Han, Qian Wang, Junmin Peng, Bin Zhang, and '''Zhenyu Yue''' (2023) Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence '''''Nature Cell Biology'',''' Jul;25(7):963-974.<ref>{{Cite journal |last=Choi |first=Insup |last2=Wang |first2=Minghui |last3=Yoo |first3=Seungyeul |last4=Xu |first4=Peng |last5=Seegobin |first5=Steven P. |last6=Li |first6=Xianting |last7=Han |first7=Xian |last8=Wang |first8=Qian |last9=Peng |first9=Junmin |last10=Zhang |first10=Bin |last11=Yue |first11=Zhenyu |date=2023-07 |title=Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence |url=https://pubmed.ncbi.nlm.nih.gov/37231161 |journal=Nature Cell Biology |volume=25 |issue=7 |pages=963–974 |doi=10.1038/s41556-023-01158-0 |issn=1476-4679 |pmc=PMC10950302 |pmid=37231161}}</ref>
* Qian Wang, Minghui Wang, Insup Choi, Lily Sarrafha, Marianna Liang, Lap Ho, Kurt Farrell, Kristin G. Beaumont, Robert Sebra, Claudia De Sanctis, John F Crary, Tim Ahfeldt, Joel Blanchard, Drew Neavin, Joseph Powell, David A. Davis, Xiaoyan Sun, Bin Zhang, '''Zhenyu Yue''' (2024) Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson’s disease '''''Science Advance''''' Jan 12;10(2):eadi8287.<ref>{{Cite journal |last=Rolak |first=L. A. |date=1987-10 |title=Copolymer-I therapy for multiple sclerosis |url=https://pubmed.ncbi.nlm.nih.gov/2972360 |journal=Clinical Neuropharmacology |volume=10 |issue=5 |pages=389–396 |doi=10.1097/00002826-198710000-00001 |issn=0362-5664 |pmid=2972360}}</ref>
* Xiaoting Zhou, You-Kyung Lee, Xianting Li, Henry Kim, Carlos Sanchez-Priego, Xian Han, Haiyan Tan, Suiping Zhou, Yingxue Fu, Kerry Purtell, Qian Wang, Gay Holstein, Beisha Tang, Junmin Peng, Nan Yang, '''Zhenyu Yue''' (2024) Integrated proteomics reveals the landscape of autophagy degradation and an autophagy receptor controlling PKA-RI complex homeostasis in human neurons '''''Nature Communications.'''''<ref>{{Citation |last=Zhou |first=Xiaoting |title=Integrated proteomics reveals the landscape of autophagy degradation in human neurons and autophagy receptors regulating neuronal activity |date=2022-12-04 |url=https://www.biorxiv.org/content/10.1101/2022.12.04.519029v1 |access-date=2024-04-28 |language=en |doi=10.1101/2022.12.04.519029 |last2=Lee |first2=You-Kyung |last3=Li |first3=Xianting |last4=Kim |first4=Henry |last5=Sanchez-Priego |first5=Carlos |last6=Han |first6=Xian |last7=Tan |first7=Haiyan |last8=Zhou |first8=Suiping |last9=Fu |first9=Yingxue}}</ref>
== Personal life ==
Yue has been married to Yuko Kawai. They have two children.
== References ==
{{Reflist}}
== External links ==
* [https://labs.icahn.mssm.edu/yuelab/ Yue Laboratory's website]
* [https://scholar.google.com/citations?user=NYnuStIAAAAJ&hl=en Google Scholar profile for Zhenyu Yue]
{{Authority control}}
Okumaya devam et...
'''Zhenyu Yue''', PhD, is a [[distinguished]] academic researcher in the field of neurology and neuroscience, currently serving as the Alex and Shirley Aidekman Professor at the [[Icahn School of Medicine]] at [[Mount Sinai, New York]].<ref>{{Cite web |title=Zhenyu Yue {{!}} Mount Sinai - New York |url=https://profiles.mountsinai.org/zhenyu-yue |access-date=2024-04-28 |website=Mount Sinai Health System |language=en}}</ref> He is known for his discovery of genes controlling [[autophagy]] (cell self-eating), autophagy functions in [[central nervous system]], molecular mechanism of neurodegenerative diseases, and modelling neurological diseases using genetic mouse models.<ref>{{Cite journal |last=Zhou |first=Xiaoting |last2=Lee |first2=You-Kyung |last3=Li |first3=Xianting |last4=Kim |first4=Henry |last5=Sanchez-Priego |first5=Carlos |last6=Han |first6=Xian |last7=Tan |first7=Haiyan |last8=Zhou |first8=Suiping |last9=Fu |first9=Yingxue |last10=Purtell |first10=Kerry |last11=Wang |first11=Qian |last12=Holstein |first12=Gay R. |last13=Tang |first13=Beisha |last14=Peng |first14=Junmin |last15=Yang |first15=Nan |date=2024-04-10 |title=Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons |url=https://www.nature.com/articles/s41467-024-47440-z |journal=Nature Communications |language=en |volume=15 |issue=1 |pages=3113 |doi=10.1038/s41467-024-47440-z |issn=2041-1723}}</ref><ref>{{Cite web |date=2019-06-10 |title=Yue Laboratory |url=https://labs.icahn.mssm.edu/yuelab/ |access-date=2024-04-28 |website=labs.icahn.mssm.edu |language=en-US}}</ref>
== Early life & education ==
Zhenyu Yue earned a [[Bachelor of Science|Bachelor of Science (B.S.)]] degree in Cell Biology from [[Wuhan University]] in China in 1988. He then obtained a Master of Science (M.S.) degree in Vertebrate Genetics from the Institute of Hydrobiology at the [[Chinese Academy of Science]], also in [[Wuhan, China]], in 1991.<ref>{{Cite web |title=research.com |url=https://research.com/u/zhenyu-yue}}</ref> In pursuit of further education, Yue relocated to the United States, where he embarked on doctoral studies in [[Molecular Biology]] and [[Biochemistry]]. He conducted his Ph.D. research under the mentorship of Aaron J Shatkin, a member of the National Academy of Sciences, at UMDNJ-Rutgers, [[Robert Wood Johnson Medical School]] in New Jersey.<ref>{{Cite web |title=Zhenyu Yue, PhD {{!}} Parkinson's Disease |url=https://www.michaeljfox.org/researcher/zhenyu-yue-phd |access-date=2024-04-28 |website=www.michaeljfox.org |language=en}}</ref> His doctoral studies, which spanned from 1992 to 1997, focused on virus biology and [[Messenger RNA|mRNA]] modifications. The highlight of this Ph.D. thesis is the identification of human mRNA capping enzyme, which is a significant contribution to the understanding of mRNA biology, and has yielded the patent “mRNA Capping and Use thereof”.<ref>{{Cite patent|number=US6312926B1|title=mRNA capping enzymes and uses thereof|gdate=2001-11-06|invent1=Shatkin|invent2=Pillutla|invent3=Reinberg|invent4=Maldonado|inventor1-first=Aaron J.|inventor2-first=Renuka|inventor3-first=Danny|inventor4-first=Edio|url=https://patents.google.com/patent/US6312926B1/en}}</ref>
Following the completion of his Ph.D., Yue engaged in postdoctoral research at the [[Howard Hughes Medical Institute]]/[[The Rockefeller University]] in New York. From 1998 to 2002, he worked under the guidance of Nathaniel Heintz, Ph.D., a Howard Hughes Medical Institute investigator, specializing in molecular biology and neuroscience. He reported the first autophagy gene disruption mouse models, which revealed a link of autophagy to [[Carcinogenesis|tumorigenesis]].<ref>{{Cite journal |last=Deng |first=Zhiqiang |last2=Dong |first2=Yu |last3=Zhou |first3=Xiaoting |last4=Lu |first4=Jia-Hong |last5=Yue |first5=Zhenyu |date=2022-04-01 |title=Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles |url=https://www.sciencedirect.com/science/article/pii/S2211383521004810 |journal=Acta Pharmaceutica Sinica B |volume=12 |issue=4 |pages=1688–1706 |doi=10.1016/j.apsb.2021.12.009 |issn=2211-3835 |pmc=PMC9279633 |pmid=35847516}}</ref> Yue pioneered autophagy research in neurodegeneration using ''Lurcher'' mice.<ref>{{Cite journal |last=Yue |first=Zhenyu |last2=Horton |first2=Antony |last3=Bravin |first3=Monica |last4=DeJager |first4=Philip L. |last5=Selimi |first5=Fekrije |last6=Heintz |first6=Nathaniel |date=2002-08 |title=A Novel Protein Complex Linking the δ2 Glutamate Receptor and Autophagy |url=https://doi.org/10.1016/s0896-6273(02)00861-9 |journal=Neuron |volume=35 |issue=5 |pages=921–933 |doi=10.1016/s0896-6273(02)00861-9 |issn=0896-6273}}</ref>
== Research & Career ==
Zhenyu Yue's research has primarily concentrated on the molecular and cellular mechanisms underlying neurodegenerative diseases, with a particular focus on [[Parkinson’s disease]] and [[Alzheimer's disease|Alzheimer’s disease]].<ref>{{Cite web |title=Center for Parkinson’s Disease Neurobiology {{!}} Icahn School of Medicine |url=https://icahn.mssm.edu/research/center-parkinsons-disease |access-date=2024-04-28 |website=Icahn School of Medicine at Mount Sinai |language=en-US}}</ref>
One of the notable areas of Yue's research involves the study of autophagy, a cellular process that degrades and recycles cellular components. His work has led to the identification of novel autophagy regulators, such as the components in Beclin 1-hVPS34 complex (class 3 PI3K), Atg14L, Rubicon, and [[NRBF2]], which play crucial roles in the autophagy pathway.<ref>{{Cite journal |last=Funderburk |first=Sarah F. |last2=Wang |first2=Qing Jun |last3=Yue |first3=Zhenyu |date=2010-06 |title=The Beclin 1–VPS34 complex – at the crossroads of autophagy and beyond |url=https://doi.org/10.1016/j.tcb.2010.03.002 |journal=Trends in Cell Biology |volume=20 |issue=6 |pages=355–362 |doi=10.1016/j.tcb.2010.03.002 |issn=0962-8924 |pmc=PMC3781210 |pmid=20356743}}</ref><ref>{{Cite journal |last=Zhong |first=Yun |last2=Wang |first2=Qing Jun |last3=Li |first3=Xianting |last4=Yan |first4=Ying |last5=Backer |first5=Jonathan M. |last6=Chait |first6=Brian T. |last7=Heintz |first7=Nathaniel |last8=Yue |first8=Zhenyu |date=2009-04 |title=Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex |url=https://www.nature.com/articles/ncb1854 |journal=Nature Cell Biology |language=en |volume=11 |issue=4 |pages=468–476 |doi=10.1038/ncb1854 |issn=1476-4679 |pmc=PMC2664389 |pmid=19270693}}</ref> This research is significant for understanding how disruptions in cellular cleaning mechanisms can contribute to the development of neurodegenerative diseases.
Yue's research has contributed to identifying and characterizing autophagy receptors, which are implicated in neurodegenerative diseases and psychiatric disorders. For instance, SQSTM1/p62, often found in Lewy bodies, tau tangles, and huntingtin aggregates, is the prototype of autophagy receptor that regulates the clearance of polyubiquitinated protein complex and aggregate through autophagy.<ref>{{Cite journal |last=Deng |first=Zhiqiang |last2=Lim |first2=Junghyun |last3=Wang |first3=Qian |last4=Purtell |first4=Kerry |last5=Wu |first5=Shuai |last6=Palomo |first6=Gloria M. |last7=Tan |first7=Haiyan |last8=Manfredi |first8=Giovanni |last9=Zhao |first9=Yanxiang |last10=Peng |first10=Junmin |last11=Hu |first11=Bo |last12=Chen |first12=Shi |last13=Yue |first13=Zhenyu |date=2020-05-03 |title=ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway |url=https://www.tandfonline.com/doi/full/10.1080/15548627.2019.1644076 |journal=Autophagy |language=en |volume=16 |issue=5 |pages=917–931 |doi=10.1080/15548627.2019.1644076 |issn=1554-8627 |pmc=PMC7144840 |pmid=31362587}}</ref> AKAP11, a significant risk gene for bipolar and [[schizophrenia]], is an autophagy receptor that control PKA-RI complex degradation through autophagy.<ref>{{Cite journal |last=Zhou |first=Xiaoting |last2=Lee |first2=You-Kyung |last3=Li |first3=Xianting |last4=Kim |first4=Henry |last5=Sanchez-Priego |first5=Carlos |last6=Han |first6=Xian |last7=Tan |first7=Haiyan |last8=Zhou |first8=Suiping |last9=Fu |first9=Yingxue |last10=Purtell |first10=Kerry |last11=Wang |first11=Qian |last12=Holstein |first12=Gay R. |last13=Tang |first13=Beisha |last14=Peng |first14=Junmin |last15=Yang |first15=Nan |date=2024-04-10 |title=Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons |url=https://www.nature.com/articles/s41467-024-47440-z |journal=Nature Communications |language=en |volume=15 |issue=1 |pages=3113 |doi=10.1038/s41467-024-47440-z |issn=2041-1723}}</ref>
In addition to these areas, Yue's research has extended to identifying and characterizing therapeutic targets for Parkinson’s disease (PD). For instance, he has explored the role of [[LRRK2]] and [[synaptojanin 1]] signalling pathway in neurodegeneration.<ref>{{Cite journal |last=Pan |first=Ping-Yue |last2=Li |first2=Xianting |last3=Wang |first3=Jing |last4=Powell |first4=James |last5=Wang |first5=Qian |last6=Zhang |first6=Yuanxi |last7=Chen |first7=Zhaoyu |last8=Wicinski |first8=Bridget |last9=Hof |first9=Patrick |last10=Ryan |first10=Timothy A. |last11=Yue |first11=Zhenyu |date=2017-11-22 |title=Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons |url=https://www.jneurosci.org/content/37/47/11366 |journal=Journal of Neuroscience |language=en |volume=37 |issue=47 |pages=11366–11376 |doi=10.1523/JNEUROSCI.0964-17.2017 |issn=0270-6474 |pmc=PMC5700420 |pmid=29054882}}</ref> Yue’s investigation demonstrated that [[vitamin B12]] modulates LRRK2 kinase activity through [[allosteric regulation]] and confers neuroprotection.<ref>{{Cite journal |last=Schaffner |first=Adam |last2=Li |first2=Xianting |last3=Gomez-Llorente |first3=Yacob |last4=Leandrou |first4=Emmanouela |last5=Memou |first5=Anna |last6=Clemente |first6=Nicolina |last7=Yao |first7=Chen |last8=Afsari |first8=Farinaz |last9=Zhi |first9=Lianteng |last10=Pan |first10=Nina |last11=Morohashi |first11=Keita |last12=Hua |first12=Xiaoluan |last13=Zhou |first13=Ming-Ming |last14=Wang |first14=Chunyu |last15=Zhang |first15=Hui |date=2019-04 |title=Vitamin B12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection |url=https://www.nature.com/articles/s41422-019-0153-8 |journal=Cell Research |language=en |volume=29 |issue=4 |pages=313–329 |doi=10.1038/s41422-019-0153-8 |issn=1748-7838 |pmc=PMC6462009 |pmid=30858560}}</ref> Furthermore, Yue’s group has performed molecular profiling of substant nigra from the PD post-mortem brains using single nucleus RNA sequencing, and identified diverse [[dopamine]] neuron subpopulations and a novel vulnerable neuron type.<ref>{{Cite journal |last=Wang |first=Qian |last2=Wang |first2=Minghui |last3=Choi |first3=Insup |last4=Sarrafha |first4=Lily |last5=Liang |first5=Marianna |last6=Ho |first6=Lap |last7=Farrell |first7=Kurt |last8=Beaumont |first8=Kristin G. |last9=Sebra |first9=Robert |last10=De Sanctis |first10=Claudia |last11=Crary |first11=John F. |last12=Ahfeldt |first12=Tim |last13=Blanchard |first13=Joel |last14=Neavin |first14=Drew |last15=Powell |first15=Joseph |date=2024-01-12 |title=Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson’s disease |url=https://www.science.org/doi/10.1126/sciadv.adi8287 |journal=Science Advances |language=en |volume=10 |issue=2 |doi=10.1126/sciadv.adi8287 |issn=2375-2548 |pmc=PMC10780895 |pmid=38198537}}</ref> His studies provided valuable resource and insight into therapeutic targets of PD.
After concluding his postdoctoral tenure at [[The Rockefeller University]] in New York, Yue joined the Mount Sinai School of Medicine in New York, where he has developed a significant portion of his professional work.
Yue's initial appointment at Mount Sinai began in August 2004 as an Assistant Professor in the Department of Neurology & Neuroscience. His career at Mount Sinai evolved with his promotion to Associate Professor with tenure in August 2008, a position he maintained until ascending to the role of full Professor of Neurology and Neuroscience in July 2013.
In his capacity at Mount Sinai, Yue has undertaken several leadership roles, notably as the Director of Basic and Translational Research in Movement Disorders since December 2012 and, more recently, as the Director of the Center for Parkinson’s Disease Neurobiology since July 2022.
== Awards ==
Throughout his career, Zhenyu Yue has received several awards and honors that acknowledge his contributions to the fields of neurology and neuroscience, particularly in the context of his research on neurodegenerative diseases.
* In 2008, Yue was honored with the Faculty Council Award for Academic Excellence by Mount Sinai.
* Yue holds the Alex and Shirley Aidekman Family Neurological Research Professorship at Mount Sinai.
* Yue has been a recipient of the Sundaram Research Scholar Award from the Mount Sinai Medical Center in 2017, 2018, and 2019.
* Yue has been a member of Sigma Xi, The Scientific Research Honor Society, since March 2024.
In addition to his institutional honors, Yue has been actively involved with the [[Chinese Biological Investigators Society|Chinese Biological Investigator Society]] (CBIS), serving as a board member since 2016.
== Notable publications ==
* '''Zhenyu Yue''', Maldonado. E., Pillutla, RC., Cho, H., Reinberg, D. and Shatkin, AJ (1997) Mammalian capping enzyme complements mutant ''S. cerevisiae'' lacking mRNA Guanylytransferase and selectively binds the elongating form of RNA polymerase II. '''''Proc. Natl. Acad. Sci. USA''''' 94:12914-9.<ref>{{Cite journal |last=Yue |first=Z. |last2=Maldonado |first2=E. |last3=Pillutla |first3=R. |last4=Cho |first4=H. |last5=Reinberg |first5=D. |last6=Shatkin |first6=A. J. |date=1997-11-25 |title=Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II |url=https://pubmed.ncbi.nlm.nih.gov/9371772 |journal=Proceedings of the National Academy of Sciences of the United States of America |volume=94 |issue=24 |pages=12898–12903 |doi=10.1073/pnas.94.24.12898 |issn=0027-8424 |pmc=PMC24235 |pmid=9371772}}</ref>
* '''Zhenyu Yue''', Antony Horton, Monica Bravin, Philip L. DeJager, Fekrije Selimi, and Nathaniel Heintz (2002) A Novel Protein Complex linking the d2 Glutamate Receptor (GluRd2) and Autophagy: Implications for Neurodegeneration in Lurcher Mice. '''''Neuron''''' 35 (5):921-33''.''<ref>{{Cite journal |last=Yue |first=Zhenyu |last2=Horton |first2=Antony |last3=Bravin |first3=Monica |last4=DeJager |first4=Philip L. |last5=Selimi |first5=Fekrije |last6=Heintz |first6=Nathaniel |date=2002-08-29 |title=A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice |url=https://pubmed.ncbi.nlm.nih.gov/12372286 |journal=Neuron |volume=35 |issue=5 |pages=921–933 |doi=10.1016/s0896-6273(02)00861-9 |issn=0896-6273 |pmid=12372286}}</ref>
* '''Zhenyu Yue''', Victor Jin, Chingwen Yang, Arnold Levine and Nathaniel Heintz (2003) Beclin1, an autophagy gene essential for early embryonic development, is a haplo-insufficient tumor suppressor. '''''Proc. Natl. Acad. Sci. USA''''' 100 (25):15077-15082''.''<ref>{{Cite journal |last=Yue |first=Zhenyu |last2=Jin |first2=Shengkan |last3=Yang |first3=Chingwen |last4=Levine |first4=Arnold J. |last5=Heintz |first5=Nathaniel |date=2003-12-09 |title=Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor |url=https://pubmed.ncbi.nlm.nih.gov/14657337 |journal=Proceedings of the National Academy of Sciences of the United States of America |volume=100 |issue=25 |pages=15077–15082 |doi=10.1073/pnas.2436255100 |issn=0027-8424 |pmc=PMC299911 |pmid=14657337}}</ref>
* Masaaki Komatsu, Satoshi Waguri, Masato Koike, Yu-shin Sou, Takashi Ueno, Taichi Hara, Noboru Mizushima, Jun-ichi Iwata, Junji Ezaki, Shigeo Murata, Jun Hamazaki, Yasumasa Nishito, Shun-ichiro Iemura, Tohru Natsume, Toru Yanagawa, Junya Uwayama, Eiji Warabi, Hiroshi Yoshida, Tetsuro Ishii, '''Zhenyu Yue''', Yasuo Uchiyama, Eiki Kominami and Keiji Tanaka (2007) Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice Cell 131 (6): 1149-63.<ref>{{Cite journal |last=Komatsu |first=Masaaki |last2=Waguri |first2=Satoshi |last3=Koike |first3=Masato |last4=Sou |first4=Yu-Shin |last5=Ueno |first5=Takashi |last6=Hara |first6=Taichi |last7=Mizushima |first7=Noboru |last8=Iwata |first8=Jun-Ichi |last9=Ezaki |first9=Junji |last10=Murata |first10=Shigeo |last11=Hamazaki |first11=Jun |last12=Nishito |first12=Yasumasa |last13=Iemura |first13=Shun-Ichiro |last14=Natsume |first14=Tohru |last15=Yanagawa |first15=Toru |date=2007-12-14 |title=Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice |url=https://pubmed.ncbi.nlm.nih.gov/18083104 |journal=Cell |volume=131 |issue=6 |pages=1149–1163 |doi=10.1016/j.cell.2007.10.035 |issn=0092-8674 |pmid=18083104}}</ref>
* Yun Zhong, Qing-Jun Wang, Xianting Li, Brian T. Chait, Nathaniel Heintz and '''Zhenyu Yue''' (2009) Distinct Regulation of Autophagic Activity by Novel Components Atg14L and Rubicon in Beclin 1-Vps34/phosphatidylinositol (PtdIns) 3-kinase complex. '''''Nature Cell Biology''''' 11(4):468-76.<ref>{{Cite journal |last=Zhong |first=Yun |last2=Wang |first2=Qing Jun |last3=Li |first3=Xianting |last4=Yan |first4=Ying |last5=Backer |first5=Jonathan M. |last6=Chait |first6=Brian T. |last7=Heintz |first7=Nathaniel |last8=Yue |first8=Zhenyu |date=2009-04 |title=Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex |url=https://pubmed.ncbi.nlm.nih.gov/19270693 |journal=Nature Cell Biology |volume=11 |issue=4 |pages=468–476 |doi=10.1038/ncb1854 |issn=1476-4679 |pmc=2664389 |pmid=19270693}}</ref>
* Xianting Li, Jyoti C. Patel, Jing Wang, Marat V. Avshalumov, Charles Nicholson, Joeseph D. Buxbaum, Gregory A. Elder, Margaret E. Rice and '''Zhenyu Yue''' (2010) Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice is Eliminated by familial Parkinson’s Disease Mutation G2019S. '''''Journal of Neuroscience''''' 30(5):1788-1797.<ref>{{Cite journal |last=Li |first=Xianting |last2=Patel |first2=Jyoti C. |last3=Wang |first3=Jing |last4=Avshalumov |first4=Marat V. |last5=Nicholson |first5=Charles |last6=Buxbaum |first6=Joseph D. |last7=Elder |first7=Gregory A. |last8=Rice |first8=Margaret E. |last9=Yue |first9=Zhenyu |date=2010-02-03 |title=Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858426/ |journal=The Journal of Neuroscience |volume=30 |issue=5 |pages=1788–1797 |doi=10.1523/JNEUROSCI.5604-09.2010 |issn=0270-6474 |pmc=2858426 |pmid=20130188}}</ref>
* Jiahong Lu, Liqiang He, Qing Jun Wang, Christian Behrends, Brian T. Chait, Masatake Araki, Kimi Araki, Scott L. Friedman, Maria Isabel Fiel, Min Li and '''Zhenyu Yue''' (2014) NRBF2 Regulates Autophagy and Prevents Liver Injury by Modulating Beclin 1/Atg14L-Linked Class III Phosphatidylinositol-3 Kinase Activity. '''''Nature Communications''''' 22;5:3920.<ref>{{Cite journal |last=Lu |first=Jiahong |last2=He |first2=Liqiang |last3=Behrends |first3=Christian |last4=Araki |first4=Masatake |last5=Araki |first5=Kimi |last6=Jun Wang |first6=Qing |last7=Catanzaro |first7=Joseph M. |last8=Friedman |first8=Scott L. |last9=Zong |first9=Wei-Xing |last10=Fiel |first10=M. Isabel |last11=Li |first11=Min |last12=Yue |first12=Zhenyu |date=2014-05-22 |title=NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity |url=https://pubmed.ncbi.nlm.nih.gov/24849286 |journal=Nature Communications |volume=5 |pages=3920 |doi=10.1038/ncomms4920 |issn=2041-1723 |pmc=4376476 |pmid=24849286}}</ref>
* Junghyun Lim, M. Lenard Lachenmayer, Wenchao Liu, Mondira Kundu, Rong Wang, Massaki Komatsu, Young J. Oh, Yanxiang Zhao and '''Zhenyu Yue''' (2015) Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates '''''PLoS Genetics''''' Feb 27;11(2):e1004987.<ref>{{Cite journal |last=Grapin |first=C. |date=1989 |title=[Treatment of anomalies associated with ectopies] |url=https://pubmed.ncbi.nlm.nih.gov/2572348 |journal=Chirurgie Pediatrique |volume=30 |issue=3 |pages=164 |issn=0180-5738 |pmid=2572348}}</ref>
* Mitchell S. Wold, Junghyun Lim, Véronik Lachance, Zhiqiang Deng, '''Zhenyu Yue''' (2016) ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington’s disease models '''''Molecular Neurodegeneration''''' v.11; 2016.<ref>{{Cite journal |last=Wold |first=Mitchell S. |last2=Lim |first2=Junghyun |last3=Lachance |first3=Véronik |last4=Deng |first4=Zhiqiang |last5=Yue |first5=Zhenyu |date=2016-12-09 |title=ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington’s disease models |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148922/ |journal=Molecular Neurodegeneration |volume=11 |pages=76 |doi=10.1186/s13024-016-0141-0 |issn=1750-1326 |pmc=5148922 |pmid=27938392}}</ref>
* Ping-Yue Pan, Xianting Li, Jing Wang, James Powell, Qian Wang, Yuanxi Zhang, Zhaoyu Chen, Bridget Wicinski, Patrick Hof, Timothy A. Ryan, '''Zhenyu Yue''' (2017) Parkinson’s disease associated LRRK2 hyperactive kinase mutant disrupts synaptic vesicle trafficking in ventral midbrain neurons. '''''J of Neuroscience'''.'' 2017 Nov 22;37(47):11366-11376.<ref>{{Cite journal |last=Pan |first=Ping-Yue |last2=Li |first2=Xianting |last3=Wang |first3=Jing |last4=Powell |first4=James |last5=Wang |first5=Qian |last6=Zhang |first6=Yuanxi |last7=Chen |first7=Zhaoyu |last8=Wicinski |first8=Bridget |last9=Hof |first9=Patrick |last10=Ryan |first10=Timothy A. |last11=Yue |first11=Zhenyu |date=2017-11-22 |title=Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons |url=https://pubmed.ncbi.nlm.nih.gov/29054882 |journal=The Journal of Neuroscience: The Official Journal of the Society for Neuroscience |volume=37 |issue=47 |pages=11366–11376 |doi=10.1523/JNEUROSCI.0964-17.2017 |issn=1529-2401 |pmc=5700420 |pmid=29054882}}</ref>
* Adam Schaffner, Xianting Li, Yacob Gomez-Llorent, Emmanouela Leandrou, Anna Memou<sup>,</sup> Nicolina Clemente, Chen Yao, Farinaz Afsari, Lianteng Zhi, Nina Pan, Keita Morohashi, Xiaoluan Hua, Ming-Ming Zhou, Chunyu Wang, Hui Zhang, Shu G. Chen, Christopher J. Elliott, Hardy Rideout, Iban Ubarretxena-Belandia, and '''Zhenyu Yue''' (2019) Vitamin B<sub>12</sub> modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection '''''Cell Research''''' 29(4):313.<ref>{{Cite journal |last=Schaffner |first=Adam |last2=Li |first2=Xianting |last3=Gomez-Llorente |first3=Yacob |last4=Leandrou |first4=Emmanouela |last5=Memou |first5=Anna |last6=Clemente |first6=Nicolina |last7=Yao |first7=Chen |last8=Afsari |first8=Farinaz |last9=Zhi |first9=Lianteng |last10=Pan |first10=Nina |last11=Morohashi |first11=Keita |last12=Hua |first12=Xiaoluan |last13=Zhou |first13=Ming-Ming |last14=Wang |first14=Chunyu |last15=Zhang |first15=Hui |date=2019-04 |title=Vitamin B12 modulates Parkinson's disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection |url=https://pubmed.ncbi.nlm.nih.gov/30858560 |journal=Cell Research |volume=29 |issue=4 |pages=313–329 |doi=10.1038/s41422-019-0153-8 |issn=1748-7838 |pmc=6462009 |pmid=30858560}}</ref>
* Zhiqiang Deng, Junghyun Lim<sub>,</sub> Qian Wang, Kerry Purtell, Shuai Wu, Mitchell S. Wold, Gloria M. Palomo Carrasco, Haiyan Tan, Giovanni Manfredi, Yanxiang Zhao, Junmin Peng, Bo Hu, Shi Chen and '''Zhenyu Yue''' (2019) <sup> </sup> ALS/FTLD-linked mutations of p62/SQSTM1 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway '''''Autophagy''''' 2019 July 30:1-5.<ref>{{Cite journal |last=Deng |first=Zhiqiang |last2=Lim |first2=Junghyun |last3=Wang |first3=Qian |last4=Purtell |first4=Kerry |last5=Wu |first5=Shuai |last6=Palomo |first6=Gloria M. |last7=Tan |first7=Haiyan |last8=Manfredi |first8=Giovanni |last9=Zhao |first9=Yanxiang |last10=Peng |first10=Junmin |last11=Hu |first11=Bo |last12=Chen |first12=Shi |last13=Yue |first13=Zhenyu |date=2020-05 |title=ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway |url=https://pubmed.ncbi.nlm.nih.gov/31362587 |journal=Autophagy |volume=16 |issue=5 |pages=917–931 |doi=10.1080/15548627.2019.1644076 |issn=1554-8635 |pmc=7144840 |pmid=31362587}}</ref>
* Zhiqiang Deng, Xianting Li, Marian Blanca Ramirez, Kerry Purtell, Insup Choi, Qin Yu, and '''Zhenyu Yue''' (2021) Selective Autophagy of AKAP11 Activates cAMP/PKA to Fuel Mitochondrial Metabolism and Tumor Cell Growth '''''Proc Natl Acad Sci USA''''' Apr 6;118(14):e2020215118.<ref>{{Cite journal |last=Deng |first=Zhiqiang |last2=Li |first2=Xianting |last3=Blanca Ramirez |first3=Marian |last4=Purtell |first4=Kerry |last5=Choi |first5=Insup |last6=Lu |first6=Jia-Hong |last7=Yu |first7=Qin |last8=Yue |first8=Zhenyu |date=2021-04-06 |title=Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth |url=https://pubmed.ncbi.nlm.nih.gov/33785595 |journal=Proceedings of the National Academy of Sciences of the United States of America |volume=118 |issue=14 |pages=e2020215118 |doi=10.1073/pnas.2020215118 |issn=1091-6490 |pmc=8040602 |pmid=33785595}}</ref>
* Insup Choi, Minghui Wang, Seungyeul Yoo, Peng Xu, Steven P. Seegobin, Xianting Li, Xian Han, Qian Wang, Junmin Peng, Bin Zhang, and '''Zhenyu Yue''' (2023) Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence '''''Nature Cell Biology'',''' Jul;25(7):963-974.<ref>{{Cite journal |last=Choi |first=Insup |last2=Wang |first2=Minghui |last3=Yoo |first3=Seungyeul |last4=Xu |first4=Peng |last5=Seegobin |first5=Steven P. |last6=Li |first6=Xianting |last7=Han |first7=Xian |last8=Wang |first8=Qian |last9=Peng |first9=Junmin |last10=Zhang |first10=Bin |last11=Yue |first11=Zhenyu |date=2023-07 |title=Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence |url=https://pubmed.ncbi.nlm.nih.gov/37231161 |journal=Nature Cell Biology |volume=25 |issue=7 |pages=963–974 |doi=10.1038/s41556-023-01158-0 |issn=1476-4679 |pmc=PMC10950302 |pmid=37231161}}</ref>
* Qian Wang, Minghui Wang, Insup Choi, Lily Sarrafha, Marianna Liang, Lap Ho, Kurt Farrell, Kristin G. Beaumont, Robert Sebra, Claudia De Sanctis, John F Crary, Tim Ahfeldt, Joel Blanchard, Drew Neavin, Joseph Powell, David A. Davis, Xiaoyan Sun, Bin Zhang, '''Zhenyu Yue''' (2024) Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson’s disease '''''Science Advance''''' Jan 12;10(2):eadi8287.<ref>{{Cite journal |last=Rolak |first=L. A. |date=1987-10 |title=Copolymer-I therapy for multiple sclerosis |url=https://pubmed.ncbi.nlm.nih.gov/2972360 |journal=Clinical Neuropharmacology |volume=10 |issue=5 |pages=389–396 |doi=10.1097/00002826-198710000-00001 |issn=0362-5664 |pmid=2972360}}</ref>
* Xiaoting Zhou, You-Kyung Lee, Xianting Li, Henry Kim, Carlos Sanchez-Priego, Xian Han, Haiyan Tan, Suiping Zhou, Yingxue Fu, Kerry Purtell, Qian Wang, Gay Holstein, Beisha Tang, Junmin Peng, Nan Yang, '''Zhenyu Yue''' (2024) Integrated proteomics reveals the landscape of autophagy degradation and an autophagy receptor controlling PKA-RI complex homeostasis in human neurons '''''Nature Communications.'''''<ref>{{Citation |last=Zhou |first=Xiaoting |title=Integrated proteomics reveals the landscape of autophagy degradation in human neurons and autophagy receptors regulating neuronal activity |date=2022-12-04 |url=https://www.biorxiv.org/content/10.1101/2022.12.04.519029v1 |access-date=2024-04-28 |language=en |doi=10.1101/2022.12.04.519029 |last2=Lee |first2=You-Kyung |last3=Li |first3=Xianting |last4=Kim |first4=Henry |last5=Sanchez-Priego |first5=Carlos |last6=Han |first6=Xian |last7=Tan |first7=Haiyan |last8=Zhou |first8=Suiping |last9=Fu |first9=Yingxue}}</ref>
== Personal life ==
Yue has been married to Yuko Kawai. They have two children.
== References ==
{{Reflist}}
== External links ==
* [https://labs.icahn.mssm.edu/yuelab/ Yue Laboratory's website]
* [https://scholar.google.com/citations?user=NYnuStIAAAAJ&hl=en Google Scholar profile for Zhenyu Yue]
{{Authority control}}
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